Nicholas Clifton, PhD, AFHEA

Bio

My research focuses on studying gene expression patterns of biological pathways associated with psychiatric disorders. I use multi-omics approaches to track expression dynamics across development and apply these data to questions about genetic risk with bioinformatics.

Research Posts

University of Exeter Senior Research Fellow, Exeter Medical School | 2022-Present

Cardiff University Research Associate, MRC Centre for Neuropsychiatric Genetics and Genomics | 2021-2022

Cardiff University Research Fellow, Neuroscience and Mental Health Research Institute | 2018-2021

Cardiff University Early Career Research Fellow, Neuroscience and Mental Health Research Institute | 2016-2018

Selected Publications

Clifton NE, Bosworth ML, Haan N, Rees E, Holmans PA, Wilkinson LS, Isles AR, Collins MO, Hall J (2022). Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function. Human Molecular Genetics, https://doi.org/10.1093/hmg/ddac105.
Clifton NE, Collado-Torres L, Burke EE, Pardinas AF, Harwood JC, Di Florio A, Walter JTR, Owen MJ, O’Donovan MC, Weinberger DR, Holmans PA, Jaffe AE, Hall J (2021). Developmental profile of psychiatric risk associated with voltage-gated cation channel activity. Biological Psychiatry, https://doi.org/10.1016/j.biopsych.2021.03.009.
Clifton NE, Rees E, Holmans PA, Pardinas AF, Harwood JC, Di Florio A, Kirov G, Walter JTR, O’Donovan MC, Owen MJ, Hall J, Pocklington, AJ (2020). Genetic association of FMRP targets with psychiatric disorders. Molecular Psychiatry, https://doi.org/10.1038/s41380-020-00912-2.
Clifton NE, Hannon E, Harwood JC, Di Florio A, Thomas KL, Holmans PA, Walters JTR, O’Donovan MC, Owen MJ, Pocklington AJ, Hall J (2019). Dynamic expression of genes associated with schizophrenia and bipolar disorder across development. Translational Psychiatry, 9, 74. https://doi.org/10.1038/s41398-019-0405-x.

Apps and Tools

authentiSci | Browser extension allowing scientists to provide feedback on the validity of online science news

Block the Flock | Competitive Android game, built in Unity

Bio

Research Posts

University of Exeter Senior Research Fellow, Exeter Medical School | 2022-Present

Cardiff University Research Associate, MRC Centre for Neuropsychiatric Genetics and Genomics | 2021-2022

Cardiff University Research Fellow, Neuroscience and Mental Health Research Institute | 2018-2021

Cardiff University Early Career Research Fellow, Neuroscience and Mental Health Research Institute | 2016-2018

Selected Publications

Clifton NE, Bosworth ML, Haan N, Rees E, Holmans PA, Wilkinson LS, Isles AR, Collins MO, Hall J (2022). Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function. Human Molecular Genetics, https://doi.org/10.1093/hmg/ddac105.

Clifton NE, Collado-Torres L, Burke EE, Pardinas AF, Harwood JC, Di Florio A, Walter JTR, Owen MJ, O’Donovan MC, Weinberger DR, Holmans PA, Jaffe AE, Hall J (2021). Developmental profile of psychiatric risk associated with voltage-gated cation channel activity. Biological Psychiatry, https://doi.org/10.1016/j.biopsych.2021.03.009.

Clifton NE, Rees E, Holmans PA, Pardinas AF, Harwood JC, Di Florio A, Kirov G, Walter JTR, O’Donovan MC, Owen MJ, Hall J, Pocklington, AJ (2020). Genetic association of FMRP targets with psychiatric disorders. Molecular Psychiatry, https://doi.org/10.1038/s41380-020-00912-2.

Clifton NE, Hannon E, Harwood JC, Di Florio A, Thomas KL, Holmans PA, Walters JTR, O’Donovan MC, Owen MJ, Pocklington AJ, Hall J (2019). Dynamic expression of genes associated with schizophrenia and bipolar disorder across development. Translational Psychiatry, 9, 74. https://doi.org/10.1038/s41398-019-0405-x.